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产品型号：50ul;100ul

更新时间：2024-12-26

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品牌	其他品牌	纯度	100
货号	bs-0483R	规格	50u;100ul
供货周期	现货	主要用途	科研实验
应用领域	医疗卫生,化工,生物产业,综合

基本信息

产品编号	bs-0483R
英文名称	Rabbit Anti-Centromeric histone H3-like protein-2 antibody
中文名称	组蛋白H3样抗体
别名	centromere-specific H3 variant protein; Centromeric histone H3-like protein 2; Centromeric histone H3-like protein-2; cenp-A; A4PIF1_BRAJU.
产品类型	植物抗体
组蛋白H3样抗体研究领域	肿瘤免疫学发育生物学转录调节因子植物
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	(predicted: Brassica juncea)
产品应用	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理论分子量	20kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from Brassica juncea Centromeric histone H3-like protein-2: 3-19/178
亚型	IgG
纯化方法	affinity purified by Protein A
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
产品介绍	Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2.